ABSTRACT

Objective: Diabetes blood sugar level fluctuates in chronic anti-diabetic medication. Furthermore, lipid assay value is higher, assessing the risk factor to prevent complications in diabetes and its associated diseases difficult. Previous studies confirm the association between lipid and insulin sensitivity. However, the compound effect of blood glucose, highdensity lipoprotein ratio versus cholesterol, blood glucose ratio has not been assessed so far in insulin-resistant non-insulin-dependent diabetes. The present study aimed at calculating the novel ratio, Fasting blood sugar/High-density lipoprotein (FBS/HDL) ratio versus Cholesterol/Fasting blood sugar (CHO/FBS) ratio and investigating the correlation to Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), and Triglyceride-glucose (TyG) index in type 2 diabetes insulin-resistant patients. Methods: The study includes 30 Type 2 Diabetic patients and 20 Non-diabetics (control). Fasting serum samples used to measure Insulin, Cholesterol, Triglyceride, HDL. A fasting plasma sample utilized to measure Plasma glucose. Results: The Fasting blood sugar/ High-density lipoprotein ratio (FBS/HDL), HOMA-IR, TyG index and the Cholesterol/Fasting blood sugar ratio (CHOLESTEROL/FBS) between Non-diabetic and Diabetic at a significance of p-value < 0.001 level. Serum insulin level showed a significant difference between Non-diabetic and Diabetic at p-value < 0.05 level. The Receiver operating characteristic curve (ROC) explains the FBS/HDL ratio and CHOLESTEROL/FBS ratio with the good value of area under the curve by 0.907 and 0.935. Conclusion: The FBS/HDL ratio versus CHOLESTEROL/FBS ratio suggests a significant correlation with each other, also with HOMA-IR, and TyG index value. Hence, we suggest beneficial risk assessment ratios in type 2 diabetes insulin resistance and its associated cardiovascular diseases complications. Keywords: Type 2 diabetes; Novel lipid, sugar ratio; TyG index; Insulin resistant, Receiver operating characteristic curve
Publication date: 01/12/2021

https://ijbpas.com/pdf/2021/December/MS_IJBPAS_2021_5780.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.12.5780