ABSTRACT

The oxidation kinetics of isatin by N-chlorosuccinimide (NCS) in acetonitrile has been investigated. The reaction follows first order kinetics with respect to [oxidant] and [H+ ] and fractional order dependence on [substrate]. A decrease in the dielectric constant of the medium increases the rate. Chloride ions positively influence the rate of the reaction. The variation of ionic strength has no significance effect on the reaction rate and addition of succinamide has retarding effect. Activation parameters of the reactions has been determined by studying the reaction at different temperature (40-55oC). Based on the kinetic results and product analysis, a probable mechanism has been proposed for the oxidation of isatin by NCS. Keywords: kinetics, oxidation, isatinand N-chlorosuccinimide
Publication date: 01/12/2021

https://ijbpas.com/pdf/2021/December/MS_IJBPAS_2021_5778.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2021/10.12.5778