Peptic ulcer is common illness where there occurs erosion in gastric mucosa further penetrating within the
lining of the stomach, duodenum (beginning of the small intestine) or oesophagus. Pathogenesis of ulcer
disease includes an imbalance between gastric offensive factors like acid, pepsin secretion, Helicobacter
pylori (H.pylori), bile salts, ethanol, lipid peroxidation, nitric oxide (NO) and defensive factors like
prostaglandins (PG’S), gastric mucus, blood flow, mucosal cell shedding, cellular renovation,
glycoproteins, mucin secretion, and antioxidant enzymes like superoxide dismutase (SOD), catalase
(CAT) and glutathione levels. Modern management methods of ulcer include inhibition of gastric acid
secretion, promoting gastro protection, blocking apoptosis and stimulation of epithelial cell-proliferation
for effective healing. In this experimental study wistar rats were assessed of gastric ulcer by 2 methodsethanol induced and pylorus ligated Shay rat model. Rats were divided into six groups I, II, III, IV, V
each of which contains five animals. Group I -Control, Group II - Pylorus ligated/Ethanol induced
(negative control), Group III - Pylorus ligated/Ethanol induced and treated with Omeprazole (positive
control), Group IV- Pylorus ligated/Ethanol induced and treated with test drug HAHU 200mg, Group V-Pylorus ligated/Ethanol induced and treated with test drug HAHU 400mg. The treatment protocol was
followed for 14 days. Animals were sacrificed on 15th day, gastric mucosal were observed.
Findings suggest that Group III, Group IV, Group V showed significant protection against gastric ulcer
induced by Ethanol and pylorus ligation in rat models. They have Antioxidant and Antiulcer activity and
can be utilized in near future to provide gastric protection.
Keywords: Antiulcer, Anti-Oxidant, Hylocereus undatus
Publication date: 01/12/2021
https://ijbpas.com/pdf/2021/December/MS_IJBPAS_2021_5772.pdf
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https://doi.org/10.31032/IJBPAS/2021/10.12.5772
