ABSTRACT

Objective: To develop ezetimibe tablets using liquisolid technique to increase the solubility of ezetimibe tablets when compared to conventional tablets. Methods: Ezetimibe liquisolid tablets were prepared by using liquisolid technique. The ezetimibe liquisolid formulations were characterized by pre- and post-compression parameters. Results: Materials such as Aerosil, HPMC, grades of polyethylene glycol (PEG) showed an impact on parameters such as angle of repose, thickness, and hardness and drug release as shown in the graphs below. Conclusion: In conclusion, the liquisolid technique was believed as a capable approach to enhance the ezetimibe solubility, Dissolution rate, Bio availability. Keywords: Carrier powder, coating material, dissolution efficiency; liquisolid compact; poorly soluble, similarity factor
Publication date: 01/12/2021

https://ijbpas.com/pdf/2021/December/MS_IJBPAS_2021_5764.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.12.5764