ABSTRACT

Resealed erythrocyte is novel drug delivery system mainly used for targeting specific tissues with drug. This drug delivery system is having number of advantages over the other novel drug delivery system in case of the diseases like cancer. There are various methods used for preparation of resealed erythrocyte. In this study, we have prepared Resealed erythrocytes by two techniques, Dilution technique and preswell dilution technique by adding cross linking agent, glutaraldehyde due to which % encapsulation efficiency was increased and the results were obtained. With these results, we found that, in vitro drug release followed first order kinetics with sustained release. The % encapsulation efficiency was more with the formulations prepared by preswell technique as compared to dilution technique. The hematological parameters were satisfactory. The other parameters like particle size, zeta potential, osmotic shock, osmotic fragility, turbulent shock studies, stability study were tested for the optimized formulations. This drug delivery system has exclusive advantages over conventional drug delivery systems and hence proved to be potential in clinical point of view. Keywords: Dilution, % Encapsulation Efficiency, Glutaraldehyde, Preswell, Resealed Erythrocytes
Publication date: 01/12/2021

https://ijbpas.com/pdf/2021/December/MS_IJBPAS_2021_5761.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.12.5761