ABSTRACT

In this study, it was studied the thermal decomposition of pefloxacin mesylate and some mixture with excipients containing the same active compound using DSC technique. The kinetic parameters were obtained from DSC curves using nitrogen under dynamic atmosphere and maintaining at constant temperature range. The data showed that the pefloxacin mesylate –active substance is thermally more stable than the mixtures with any excipient. The decrease in stability was attributed to the presence of excipients in formulation and to their possible interactions with the pefloxacin mesylate the difference in stability is bigger between the pure substance and the mixture with the magnesium stearate. Keywords: Pefloxacin mesylate ; degradation behaviour; excipient; activation energy
Publication date: 01/12/2021

https://ijbpas.com/pdf/2021/December/MS_IJBPAS_2021_5747.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.12.5747