ABSTRACT

A series of new Isatin derivatives have been designed, synthesized and characterized by IR, ¹HNMR, and mass spectral data. The synthesized compounds were screened for in vitro anti-inflammatory activity by colorimetric COX (ovine) inhibitor screening assay kit. IC50 values of these compounds were determined. Among the series, compounds XIIc, XIIb, XIIf, XIIg and XIIh exhibited more potent anti-inflammatory activity. Remaining compounds showed mild to moderate anti-inflammatory activity. Results were compared with standard drug Indomethacin. Compound substituted with halogen derivatives are more active than others, but when compared with Indomethacin these are less active. Keywords: Isatin, Oxadiazine, Synthesis, Anti-inflammatory activity, Cyclooxygenase
Publication date: 01/11/2021

https://ijbpas.com/pdf/2021/November/MS_IJBPAS_2021_NOV_SPCL1024.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2021/10.11.1024