ABSTRACT

Pancreatic lipase or triglycerol acylhydrolase, the major lipolytic enzyme synthesized and secreted by the pancreas, plays an important role in the efficient digestion of triglycerides. Pancreatic lipase is responsible for the hydrolysis of 50-70% of the total dieatary fats. It removes fatty acids from the ? –apdsitions of dietary triglycerides, yielding ?-monoglycerides and long chain saturated and poly unsaturated fatty acids as the lipolytic products. The bioactive heterocyclic compounds present an exciting opportunity. Inhibition of digestive enzymes is one of the most widely studied mechanisms used to determine the potential efficacy of anti-obesity agents. The majority of pharmacetutical products that mimic heterocyclic compounds can and do participate in chemical reactions in the humanbody. The present study describes about the synthesis and the present study describes about the synthesis and characterization and biological studies of novel alkyl/halo substituted cyanoacetyl hydrazone derivatives. The synthesized compounds were characterized by FT-IR, 1H-NMR and 13C-NMR spectral studies. From this study it is obvious that the compounds inhibit the activity of pancreatic lipase, which indicates its protective role in treating obesity. The present study also confirmed that the ease of nucleophilic substitution depends on nucleophilicity. All these observations gave impetus to start a research program for the synthesis of new hydroazone derivatives containing the heterocyclic fraction. Keywords: cyanoacetyl hydrazone, pancreaticlipase, anti-obesity
Publication date: 01/11/2021

https://ijbpas.com/pdf/2021/November/MS_IJBPAS_2021_NOV_SPCL1022.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.11.1022