ABSTRACT

From the mannich base 2-((2,6-dioxocyclohexyl) (2-hydroxyphenyl) methyl) hydrazine carboxamide (1), a series of metal(II) complexes (1a-1e) ML with M = Cu(II), Ni(II), Fe(II), Cr(II), and Mn(II) were prepared and studied by electronic, IR, and NMR (1H & 13C ) spectra, and molar conductivity measurements. The complexes are nonelectrolytes, according to conductivity measurements. All complexes have octahedral geometry, according to spectroscopy and other analytical investigations. The disc diffusion technique was used to test the antibacterial activity of ligand (1) and metal complexes (1a-1e) against Staphylococcus aureus, Escherichia coli, Klebsiella pneumaniae, and Pseudomonas aeruginosa. The metal complexes (1a-1e) were more effective than the control Ciprofloxacin. Keywords: Mannich base, Transition metal complexes, Antibacterial activity, Staphylococcus aureus
Publication date: 01/11/2021

https://ijbpas.com/pdf/2021/November/MS_IJBPAS_2021_NOV_SPCL1010.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.11.1010