ABSTRACT

Diabetes mellitus is a metabolic disorder characterized by a loss of glucose homeostasis by disturbances of carbohydrate, fat and protein metabolism. The world prevalence of diabetes among adults is expected to be 6.4%, affecting 285 million adults, in 2010, and will increase to 7.7%. The number of diabetes mellitus cases has been increasing worldwide in recent years. In 2000, the world health organization estimated a total of 171 million people with diabetes mellitus from the global population, and this report projected to increase to 366 million by 2030. Considering the importance of this disease the present study is designed to analyze the phytochemical constituents and the anti- diabetic activity of the medicinally important plant species Anisomeles malabarica;(L.) R.Br. ex Sims and Mirabilis jalapa; (L.) collected from Pachaiyappas college campus in Chennai district of Tamil nadu, India . The fresh leaves of the above plants were used after they dried and powdered for extraction with ethanol solvent. The crude ethanolic leaf extract were screened both qualitatively and quantitative pattern of phytochemical constituents. The results of the study showed the presence of alkaloids, saponins ,protein,tanin and terpenoids in both the species at moderate to higher level . Higher amount of phytoconstituents such as Flavonoids, Alkaloids, Phenols, Terpenoids and Tanins was observed in M.jalapa when compared to A.malabarica. The alpha glucosidase activity of ethanolic crude extract of above plants was assayed and observed as 87.19±0.28 (100?g/ml)for M.jalapa and 68.16±0.19(100?g/ml) for A. malabarica . The alpha amylase activity was found to be 73.28 ±0.24 and 88.07 ±0.34 (100?g/ml) for A. malabarica and M.jalapa respectively at 100?g/ml. From the present study, it was found that ethanolic leaf extract of M.jalapa possessed high antidiabetic activity and found to have potential phytochemical compounds. Keywords: Anisomeles malabarica, Mirabilis Jalapa, alpha-amylase and alpha-glucosidase
Publication date: 01/11/2021

https://ijbpas.com/pdf/2021/November/MS_IJBPAS_2021_NOV_SPCL1006.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.11.1006