ABSTRACT

The aim of this experiment was to analyze the in-vitro fibrinolytic activity of Ayurvedic herbs, Aloe Barbadensis M., Hibiscus rosa-sinensis L. and Curcuma longa L. by using their herbal aqueous extracts on a dose dependent manner at different time intervals. This is to compare the efficacy of the herbal variants against the synthetic drugs used for treating thromboembolic disorders. As long-term medication of these, lead to lethal side effects of the body. Herbal extracts of Aloe vera, Hibiscus and Curcuma longa at time intervals of 24 hrs, 48 hrs and 72 hrs at 37? were observed. Streptokinsae (S.K) was chosen as a positive control and distilled water as a negative control. Percentage of clot lysis in 24 hrs for Aloe, Hibiscus and Curcumin were 38.60%, 26.93% and 22.34% respectively. In 48 hrs the readings were, 53.55%, 46.54% and 39.28% respectively. In 72 hrs it was, 73.24%, 62.56% and 52.96% respectively. Based on the results it was observed that the maximum clot lysis was noted with Aloe extracts at 72 hrs interval with 73.24% while the least lysis was observed in Curcumin with 52.96% at 72 hrs. Hence, it can be inferred that Ayurvedic extracts showed significant clot lysis with little to no side-effects possible and the relatively high lysis capacity with Aloe extract alone proves to serve as a better alternative to synthetic drugs in future. Keywords: Fibrinolysis, Streptokinase, Haematology, Physiology, Phytopharmacology and Ayurveda
Publication date: 01/11/2021

https://ijbpas.com/pdf/2021/November/MS_IJBPAS_2021_5713.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.11.5713