ABSTRACT

Aim and objective of the study: The central and peripheral mechanisms underlying the analgesic effects of Rubiadin, a major isolated phyto constituent of Rubia cordifolia Linn, was evaluated in mice using the acetic acid-induced writhing and hot plate tests. Materials and methods: a) Writhing was induced by intraperitoneal injection of 0.6% acetic acid (v/v) (80 mg/kg body wt.) and the number of muscular contractions were counted for 30 min following acetic acid injection with animals treated with Rubiadin. b) The assay was performed according to the classical hot-plate technique of Eddy and Leimbach. The parameter evaluated was the latency time for paw licking and jumping responses after exposure to the hot plate surface. Results: Results showed that Rubiadin administered intraperitoneally can significantly attenuate acetic acid-induced writhing in mice in a dose-dependent manner. In the hot plate latency test, Rubiadin showed common activity in prolonging duration time and caused marked inhibition of acetic acid induced pain. Conclusions: These findings of the current study imply the involvement of both peripheral and central antinociceptive mechanisms in observe analgesic potential of Rubiadin. Keywords: Rubiadin, analgesic activity, writhing test & hot plate test
Publication date: 01/11/2021

https://ijbpas.com/pdf/2021/November/MS_IJBPAS_2021_5707.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.11.5707