ABSTRACT

Aim of the present work was to evaluate the effect of theophylline on the positive inotropic effect of milrinone used in the treatment of congestive heart failure. The positive inotropic effect of milrinone alone and in presence of theophylline was evaluated in frog heart and guinea pig left atria. Cumulative dose response study of milrinone alone and along with theophylline was performed. The results of the study demonstrated an enhancement in the inotropic effect of milrinone when given along with theophylline. The mechanism of positive inotropic effect of milrinone involves increase in intracellular cyclic AMP by inhibiting phosphodiesterase enzyme III while theophylline is non-specific phosphodiesterase enzyme inhibitor and produces weak positive inotropic effect. The study revealed that theophyline produces synergism with milrinone in producing positive inotropic effect. Keywords: Milrinone, theophylline, positive inotropic effect, congestive heart failure and phosphodiesterase enzyme
Publication date: 01/11/2021

https://ijbpas.com/pdf/2021/November/MS_IJBPAS_2021_5699.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.11.5699