ABSTRACT

Objective: The aim of this population-based study was to elucidate differential diagnostic potential of human epididymis protein (HE4) correlation with the putative CA125 in Ultrasonogarphically (USG) confirmed patients. Study Design: The study design included 15 ultrasonographically confirmed patients with benign ovarian cysts and 9 self-reported apparently healthy subjects. Materials and Methods: In this study, nine control samples and fifteen samples from patients suffering from ultrasonographically diagnosed benign ovarian cysts were collected. Samples were collected by considering Inclusion and Exclusion criteria. Results: The mean concentration of HE4 and CA125 were analyzed in Ultrasonogarphically (USG) confirmed patients. Receiver Operator Curve (ROC) was insignificant for both the biomarkers, ( HE4 P= 0.42; CA 125 P= 0.70),but AUC ( Area Under the Curve) predicted HE4 as a better biomarker (AUC HE4:0.65 ; AUC CA125 :0.55).Moreover, combining ROMA ( Risk of Malignancy Algorithm) with HE4 or CA 125 showed HE4 as a promising biomarker than CA 125, P< 0.0001, P=0.2833 respectively Conclusion: Ultrasonography is a gold standard to diagnose pelvic masses/gynecological diseases, in correlation with HE4 and CA125. Keywords: HE4, CA125, Pelvic masses, Benign ovarian cysts, Conventional Biomarker
Publication date: 01/11/2021

https://ijbpas.com/pdf/2021/November/MS_IJBPAS_2021_5698.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.11.5698