ABSTRACT

Objectives: To determine the nature of phytoconstituents present in Calotropis gigantea Linn, plant extracts. Evaluate the potential of Calotropis Gigantea, plant extracts for Anti-Fungal Activity and Preparation & evaluation of anti-tuberculosis herbal formulation. Methodology: Calotropis gigantea plant extract which is successively extracted in various non-polar to polar solvents. Performing preliminary phytochemical for Calotropis gigantea plant extract. Perform TLC & comparative TLC for methanolic extract. Flavonoid content phenolic content and antioxidant activity were performed with methanolic extract. And perform comparative microbial test of Calotropis Gigantea, plant extract in various strains. Formulations were prepared and perform evaluation parameter. Results: Calotropis Gigantea, plant extract showed the maximum presence of secondary metabolites in methanolic extract. The total flavonoid content were found to be 7.10 ± 0.141 and 8.89 ± 0.677 mg of QE/g in methanol extract and total phenolic content was found to be 6.78 ± 0.036 and 8.56 ±1.69 mg of GA/g in methanol extract and Calotropris gigantea, plant extract showed significant antioxidant activity in methanolic extract.The comparative microbial study with fungi and bacteria shows good results against Candida albicans and thus herbal topical formulation of Calotropis gigantea, extractcan be used to treat Candidiasis. Conclusion: From this study, we concluded that Calotropis Gigantea, plant Extracts have potent Antifungal activity. Keywords: Anti-fungal, Calotropis gigantea Linn, methanolic extract, microbial, Candida albicans
Publication date: 01/10/2021

https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_OCT_SPCL_1030.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.10.1030