ABSTRACT

Objectives: Validate the study of phytoconstituents from the extracts of Amorphophallus paeoniifolius tubers for the Anti-Inflammatory activity and prepare the extract into gel form and evaluate the gel formulation for anti-inflammatory study. Methodology: Amorphophallus paeoniifolius tuber extract which was successively extracted in various non-polar to polar solvents. Performed preliminary phytochemical tests for Amorphophallus paeoniifolius tuber extract. The extract was evaluated for Flavonoid content, phenolic content and antioxidant activity. HRBC study for Anti- Inflammatory activity for various extract was performed. TLC & comparative TLC for methanolic extract was carried out. Comparative microbial test of Amorphophallus paeoniifolius tuber extract with marketed formulation on S.aureus stains. Formulations were prepared and evaluated on different parameters. Results: Amorphophallus paeoniifolius tuber extract showed the maximum presence of secondary metabolites in methanolic extract. The total flavonoid content were found to be 11.13 ± 0.118 and 14.83± 0.455 mg of QE/g in methanol extract and total phenolic content was found to be 8.54 ± 0.043 and 10.26 ± 1.66 mg of GA/g in methanol extract and Amorphophallus paeoniifolius tuber extract showed significant antioxidant activity in methanolic extract. Methanolic extract showed the maximum anti-inflammatory activity for HRBC. The comparative microbial study with marketed formulation shows good results and thus herbal formulation of Amorphophallus paeoniifolius tuber may be used to cure Inflammation. Conclusion: From this study, we concluded that Amorphophallus paeoniifolius tuber may be used for the inflammation. Keywords: anti-inflammatory, Amorphophallus paeoniifolius, methanolic extract, microbial, HRBC
Publication date: 01/10/2021

https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_OCT_SPCL_1029.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.10.1029