ABSTRACT

The plant Moringa oleifera Lam. is a small monogeneric family, the Moringaceae. It is called as “Miracle Tree” and the most widely cultivated species allover India and in tropical and subtropical regions. In Moringa all its parts like leaves, stem bark, root bark, flowers, fruits and seeds are used in different systems of medicines and used in food products for their immense neutraceutical potential. This present study evaluated the pharmacognostical features of the stem part and also tried to screen for the antiurolithiatic effect and antimicrobial effect of moringa tree stem bark. The microscopical evaluation of the plant stem has been studied and documented, it has been used for the documentation and future reference purposes. The antimicrobial activity of the test sample extracts were carried out by standard disc diffusion method (Kirby Bauer method). The antiurolithiatic effect of the fresh juice, methanol and water extract of stem bark of the plant was evaluated using ethylene glycol induced hyperoxaluria model in rats. The acute oral toxicity study was carried out as per the guidelines set by (OECD). The LD50 and ED50 of the extracts were calculated. Albino rats were selected and given 1% ethylene glycol in drinking water to induce hyperoxaluria. In six groups the oral administration of the fresh juice, aqueous and methanol extract of the drug, the others are standard and control at the dose of 200mg/kg. After 14th and 28th day of treatment urine was collected and estimated for ionic concentrations. In vivo antioxidant activity parameters such as Lipid peroxidation, Superoxide dismutase, Glutathione, Catalase were also monitored. The drug treated group animals were resulted in significant reduction in the bladder stones compared to the control and standard cystone treated group and it shows significant enzyme activity for antioxidant like reduction in MDA and increased GSH and antioxidant enzyme likes SOD and CAT in the order of fresh juice > methanol extract > aqueous extracts. The action of herbal drugs exerts their antilithogenic properties by altering the ionic composition of urine. The extracts were showed significant antimicrobial activity towards bacteria and fungi. Keywords: Moringa oleifera Lam, Antiurolithiatic, Neutraceutical, Lipid peroxidation
Publication date: 01/10/2021

https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_OCT_SPCL_1021.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.10.1021