ABSTRACT

The synthesis of novel series of structurally related benzimidazolo pyrimidines is described. Preparation of 4-(2, 3-dihydro-1H-benzimidazol-2-yl)-1-phenylpropan-1-one by using Friedel Crafts reaction in which benzene and its derivatives reacted with cyclic anhydride such as succinic anhydrides in presence of aluminium trichloride, resulted solid reacted with orthophenylenediamine in presence of sodium hydroxide to form an active hydrogen containing building block, used for synthesis of benzimidazolo pyrimidine derivatives. Twenty benzimidazolo pyrimidines derivatives was synthesized using Biginelli like reaction in which 4-(2, 3-dihydro-1H-benzimidazol-2-yl)-1-phenylpropan-1-one reacted with aldehydes and urea under acidic conditions in presence of ethanol. The acid used here was HCl. Progress of reaction was monitored by TLC. Reaction products were analysed with 1H NMR and IR spectroscopy. The anti-inflammatory activity of all synthesized derivatives was performed by Carrageenan induced rat paw oedema model. Indomethacin was used as an internal standard. All synthesized derivatives has tendency to show fall in oedema. Keywords: Benzimidazolo Pyrimidine Derivatives, Anti-Inflammatory Agents
Publication date: 01/10/2021

https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_OCT_SPCL_1013.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.10.1013