ABSTRACT

Tobramycin is an aminoglycoside antibiotic used for treating various types of bacterial infections. The conventional liquid ophthalmic delivery systems exhibit short pre-corneal residence time and the relative impermeability to the cornea which leads to poor ocular bioavailability. Ocular inserts films are the most logical delivery systems that are aimed to remain for a long period of time in the front of eye. Hence aim of present study was to prepare Tobramycin hydrochloride erodible ocular insert by solvent casting method using Gelatin and Glycerin. Ocular inserts were evaluated for physicochemical parameters such as uniformity of thickness, uniformity of weight, drug content, water absorption test (Swelling index), surface pH and in-vitro diffusion study. Prepared ocular inserts were cross linked with N,N1 - Bisacylamide (BIS) for getting sustained release of drug through ocular insert. Results of various parameters of non cross linked and cross linked ocular inserts showed that; solvent casting method is suitable for formulation of erodible ocular insert using gelatin and glycerin. Cross linked ocular insert showed sustained release of Tobramycin HCl as compared to non cross linked ocular insert. Result showed that, erodible inserts of Tobramycin HCl would be able to offer benefits such as increasing residence time, prolonging drag release, reducing frequency of administration, and thereby may help to improve patient compliance. Keywords: Tobramycin hydrochloride, Erodible Ocular Insert, Gelatin, Glycerin, Invitro diffusion study
Publication date: 01/10/2021

https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_OCT_SPCL_1011.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.10.1011