ABSTRACT

In the present work, oral thin films of Rosuvastatin were designed with a view to enhance patient compliance by solvent casting method. In the solvent casting method, ludiflash (1,2,3,4 and 5% w/w), crospovidone (1,2,3,4 and 5% w/w) as super disintegrants were used in different concentrations with Gelatin, Poly vinyl alcohol as a film forming base for the formulation of oral disintegrating thin films of Rosuvastatin by solvent casting method. The prepared formulations of films were evaluated for film thickness measurement, folding endurance study, in-vitro disintegration time, in-vitro drug release pattern (in pH 6.8 phosphate buffer). Drug content, and drug-polymers interaction study (IR spectroscopy). Among all formulations, the formulation (F5) prepared by 5% ludiflash show good drug release (98.34%). Keywords: Ludiflash, crospovidone; Rosuvastatin; oral disintegrating thin films
Publication date: 01/10/2021

https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_OCT_SPCL_1006.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2021/10.10.1006