ABSTRACT

The current work was a successful attempt to develop a bioadhesive drug delivery system for gliclazide, an orally administered anti-diabetic medication, to increase its oral bioavailability and provide long-term drug release. From the results, it can be concluded that gliclazide mucoadhesive drug delivery systems may be made utilizing polymers like guar gum by direct compression method. UV spectrophotometry method of analysis of the drug was developed. In a pH 1.2 buffer (0.1 HCL), gliclazide showed maximum absorption at 226 nm. The regression coefficient (r2) was determined to be 0.996, indicating that concentration and absorbance have a linear relationship. In the developed formulations, IR spectroscopic tests revealed no drugpolymer interaction. Without capping or chipping, all of the produced tablet formulations were determined to be satisfactory. According to the findings of this study, as the concentration of gum increases, so does the swelling index. Keywords: Bioadhesive tablet, Gliclazide, Guar gum, FTIR, Mucoadhesive strength
Publication date: 01/10/2021

https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_OCT_SPCL_1003.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.10.1003