ABSTRACT

Objective: The present research was undertaken for the development and evaluation of floating gastroretentive tablets of anticonvulsant drug gabapentin. Method: The gastroretentive tablets were made utilizing the direct compression approach. 32 factorial designs. The tablets were evaluated for different pre-compression and post-compression parameters. Besides, drug-polymer interaction was determined infrared spectroscopy using the Fourier transform and differential scanning colorimetry study. Finally, tablets were subjected to in-vivo study. Result: The results revealed that among factorial batches of floating gabapentin tablets FFG2 batch possessed longest buoyancy period (556 ± 5.23 s), the highest swelling index (103.46 percent), and the fastest drug release (99.75 %) within 12 hours. The n value of FFG2 batch was n=0.9250, indicating taht FFG2 released in a non-Fickian or aberrant manner. The ANOVA analysis for the formulations showed P-value less than 0.0500. The stability study indicates floating tablets were persistent as evident from unchanged tablet properties. The results of in vivo x-ray imaging experiments are showed that the Gabapentin-containing floating matrix tablets float in gastric fluid for up to 12 hours in the upper part of the rabbit's small intestine. As a result, tablets had long in vivo residence duration. Conclusion: The gastroretentive tablets prepared by 32 factorial designs could be beneficial and effective drug delivery strategy for the anticonvulsant drug gabapentin. Keywords: Gastroretentive, rabbit, floating tablets, gabapentin, FTIR, sustained
Publication date: 01/10/2021

https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_OCT_SPCL_1002.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.10.1002