ABSTRACT

An accurate, precise, reproducible method was developed and validated by using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) for the estimation of arsenic, lead, cadmium and mercury in Cardorium Plus Syrup. The method is selective and is capable to quantitate the respective elements in the presence of other trace elements. The method has been validated using RF power of 1300 W, plasma flow of 13 L/min, auxiliary gas flow at 0.2 L/min, nebulizer flow of 0.7 L/min with a pump rate of 1 mL/min and plasma view is at axial mode for all the elements. The wavelength was monitored for Arsenic, Lead, Cadmium and Mercury is at 193.6 nm, 220.3 nm, 228.8 nm and 253.6 nm respectively. The baseline at above stated wavelengths was good and possible inferences were not observed compared to other emission lines of elements. The method has been validated in terms of specificity, precision, linearity, accuracy, limit of quantification. The validated method can be used to estimate elements in other drug substances. The validated method can be used to estimate heavy metals using ICP-OES. Keywords: ICP-OES, Cardorium Plus, ICH, Plasma Flow, Quantification, Validation
Publication date: 25/09/2021

https://ijbpas.com/pdf/2021/September/MS_IJBPAS_2021_SEPT_SPCL_1027.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.9.1027