ABSTRACT

In present study, microwave assistedsynthesis of some novel Indole derivatives contain 1, 3- thiazole was performed. All the synthesized products were purified through column chromatography and structures of these compounds were characterized by IR, 1H NMR and mass spectral data. All the final derivatives were screened for their anticancer, antimicrobial activity and Molecular docking studies. All their efficacywas compared with standard drugs.The synthesized compound 4b, 4e, 4i and 4j are showed good Anticanceractivities whereas others exhibited significant activities. The compound 4c, 4d, 4e and 4i are has showed maximum antibacterial activity compare with streptomycin as a standard drug. The molecular docking studies of these novel derivatives of indole showed good agreement with the biological results when their binding pattern and affinity towards the active site of EGFR was investigate. Molecular docking study has been performed for all the synthesized compounds with MCFAcetylcholine-binding protein (AChBP) and results obtained are quite promising. Keywords: Indole, 1,3-thiazole, Molecular docking, Anti-bacterial, Anticancer activity
Publication date: 25/09/2021

https://ijbpas.com/pdf/2021/September/MS_IJBPAS_2021_SEPT_SPCL_1019.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.9.1019