ABSTRACT

Chronic obstructive pulmonary disease (COPD) is composed of emphysema, chronic bronchitis, and small airway obstruction caused by environmental exposures, primarily cigarette smoking. About 15- 20 percent of smokers develop COPD, so it is assumed that many host factors interact with the environment, which increases the risk of developing this disease in many patients. The major pathogenic factors that cause the disease include infection, inflammation, protease, and antiprotease imbalance that increase antioxidant defenses. The oxidant-antioxidant imbalance is recognized as one of the significant factors in COPD pathogenesis. Oxidants from cigarette smoke are the leading cause of ROS that can suppress cytokine production, including TNF-? and interleukins, via the NF-kB pathway inhibition that triggers COPD. In non-smokers, the antioxidant level is high, which reduces the risk of developing COPD than smokers who have a high oxidant level. There are multiple causesof COPD, so a multi-target therapeutic approach is necessary. In this review, we discuss the mechanism of antioxidants in COPD and the latest development. Keywords: COPD, oxidants, antioxidants, ROS
Publication date: 01/10/2021

https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_5686.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.10.5686