The main aim of this review article is to enlighten the various anti-viral drugs in single and
combination of drugs estimation by LC-MS technique. Anti-viral drugs are classified like
Nucleoside Reverse Transcriptase Inhibitors, Non-Nucleoside Reverse Transcriptase
Inhibitors, Protease Inhibitors, Fusion Inhibitors and Integrase strand transfer inhibitors and
are Zidovudine, ganciclovir, lamivudine, acyclovir, valacyclovir, ribavirin, efavirenz,
etravirenz, rilpivirine, ritonavir, saquinavir, tipranavir, simeprevir, parpitaprivir, sunaprevir,
indinavir, lopinavir, Dolutegravir, Elvitegravir, Raltegravir were estimated by using most
powerful analytical technique called LC-MS. Chromatographic parameters like different
Columns were used by various researchers for better elution and mobile phases in different
ratios andin different polarity were used for fast elution and different flow rates for proper
elution. Mass spectroscopic parameters like ionization by electron spray ionization was
mostly used with quadrupole analyzer and multiple reaction transitions were used for
detecting the compounds.
Keywords: Nucleoside Reverse Transcriptase Inhibitors, Non-Nucleoside Reverse Transcriptase
Inhibitors, Protease Inhibitors, Fusion Inhibitors and Integrase strand transfer inhibitors,
Liquid chromatography-Mass spectrometry
Publication date: 01/10/2021
https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_5677.pdf
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https://doi.org/10.31032/IJBPAS/2021/10.10.5677
