ABSTRACT

Urolithiasis is one of the most prevalent diseases among the kidney diseases. Piperine, an alkaloid obtained from dried unripe fruits of black pepper which is showing multiple pharmacological activities can also produce significant antiurolithiatic activity. Since Piperine is slightly soluble in water solid dispersion technique was used to enhance its solubility. Four solid dispersions SD1, SD2, SD3, SD4 were prepared by using different carriers in different ratios and were evaluated for parameters such as drug content, entrapment efficacy and invitro dissolution. Based on the results, SD2 was chosen as the final solid dispersion. By using SD2 solid dispersion of Piperine six formulations F1, F2, F3, F4, F5, F6 were prepared and were evaluated for precompression and post-compression parameters of tablets. Based on the results, F6 was considered as the optimized formulation. Drug release kinetics studies were performed on optimized formulation F6 and it was found that the optimized formulation F6 is following first order kinetics. In-vivo antiurolithiatic studies were performed on male wistar albino rats using F6 tablet formulation and found its significant antiurolithiatic activity. Keywords: Piperine, Antiurolithiatic activity, solid dispersion, Optimized formulation, Drug release kinetics
Publication date: 01/10/2021

https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_5673.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.10.5673