ABSTRACT

The four isolated fractions from the methanol extract of kiwi fruit pulp when tested for their anticancer potential revealed that two fractions of 7-hydroxy-2-(4-hydroxy-3- methoxyphenyl)-4h-chromen-4-one and 3’5’-dihydroxy -2’-(methoxycarbonyl methyl)- phenyl-3,4-dihydroxy benzoate had very good anticancer properties. Hence the ligands of two compounds such as 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one and 3'5'-dihydroxy -2'-(methoxycarbonyl methyl)-phenyl-3,4-dihydroxy benzoate were docked with apoptotic proteins like Caspase-3 and Beta-Actin by ArgusLab software. The docking score was highest in 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-4h-chromen-4-one ligand which showed the docking score of -10.94 kcal/mol for Caspase-3, and -9.71 kcal/mol for Beta-Actin. Likewise, 3’5’-dihydroxy -2’-(methoxycarbonyl methyl)-phenyl-3,4-dihydroxy benzoate compound showed the docking score of -8.76 kcal/mol for Caspase-3 and -9.43 kcal/mol for Beta-Actin. When compared among the ligands, 7-hydroxy-2-(4-hydroxy-3- methoxyphenyl)-4h-chromen-4-one ligand showed the least score for both Caspase-3 and Beta-Actin. Hence, 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-4h-chromen-4-one compound seems to possess higher apoptotic activity than 3’5’-dihydroxy -2’- (methoxycarbonyl methyl)-phenyl-3,4-dihydroxy benzoate compound. The interaction of 7- hydroxy-2-(4-hydroxy-3-methoxyphenyl)-4h-chromen-4-one ligand with Caspase-3 formed 4
Publication date: 01/10/2021

https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_5671.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.10.5671