ABSTRACT

Traditional Chinese Medicine (TCM) is currently used as an alternative treatment because it is considered cheaper and does not cause any side effects. Chlorogenic acid is a marker compound as a standard in a number of TCM preparations. HPLC are required not only for authentication of herbal formulations by fingerprint analysis but also for quality assurance a marker. Therefore, the aim of this literature review is to resume the method of HPLC that has been used to standardize in TCM with chlorogenic acid as a marker. This literature review focused on the type of detector for the HPLC method used in the analysis of chlorogenic acid as a marker. The results of the study showed the method HPLC-UV/Vis, HPLC-DAD, HPLCMS/ MS, HPLC-DAD-ESI/MS, and HPLC-ELSD had been used to analyze chlorogenic acid and standardized TCM. The HPLC-DAD-ESI/MS is the best method because it can perform analyses on a wider range of LOD and LOQ ranges. Keywords: Chlorogenic acid, Detector, HPLC, Standardization, TCM
Publication date: 01/10/2021

https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_5669.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.10.5669