ABSTRACT

Colorectal cancer (CRC) is one of the leading causes of mortality. The standard treatment for CRC and other cancer is generally based on using cytotoxic drugs, radiotherapy, chemotherapy, and surgery. However, the use of traditional treatments has received attention in recent years. Chemo resistance, adverse effects and disease recurrence are big challenges in the discovery of anticancer drugs. Literature review demonstrates that plant derived chemicals significantly reduced incidence rate of CRC. Plant derived chemical agents act as a prominent source of novel compounds for CRC drug discovery. Phytochemicals have been the focus of an increasing number of studies due to their ability to modulate carcinogenic processes through the alteration of multiple cancer cell survival pathways. The aim of the current review is to provide an overview of medicinal plants and their phytochemicals effective on colorectal cancer with underlying mechanisms of action. A Web of Science, PubMed, Google Scholar and Science Direct search was performed for relevant articles. Keywords: Colorectal cancer, plant, phytochemical, apoptosis, cell cycle arrest
Publication date: 01/10/2021

https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_5657.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.10.5657