ABSTRACT

Preeclampsia is a life threatening complication of pregnancy. Almost 5-6 percent of women are presented with preeclampsia in developing countries. To evaluate plasma neopterin as inflammatory marker in pregnant women with Preeclampsia. This is a cross sectional study done in south Chennai during the period of 2017-2019. After getting consent, 100 pregnant women with Gestational age 20-34 weeks was selected. Pregnant women with Diabetes, Hypertension, Renal disease, previous history of preeclampsia, multiple gestations were excluded from the study. Preeclampsia was diagnosed by gestational hypertension (?140/90mmHg) with proteinuria (24hr urine protein ?300mg) after 20 weeks of pregnancy. Of which, 25 pregnant women are diagnosed with mild preeclampsia (24hr urine protein ?300mg),25 pregnant women are diagnosed with severe preeclampsia (24hr urine protein ?5g) was considered as cases and 50 pregnant women without any pregnancy complications was considered as controls. Plasma samples were drawn from the participants for the estimation of Neopterin using EDTA vacutainers. Plasma neopterin levels less than 10nmol/L is considered normal and more than 10nmol/L is considered as elevated. Statistical analysis was done using SPSS software. There is no statistically significant mean difference between maternal age, maternal weight, gestational age during sampling time. Mean difference between Plasma neopterin levels in women with mild preeclampsia was 15.1nmol/L, pregnant women with severe preeclampsia was 16.2nmol/L and in control group, the mean plasma concentration of plasma neopterin levels was 8 nmol/L. (p value -0.001). The spearmen’s rank correlation test of plasma neopterin levels are highly correlated in women with the severity of preeclampsia (r=0.534, p=0.00), which is statistically significant. Our study data showed that Plasma neopterin concentrations are higher in pregnant women with preeclampsia than pregnant women without complications. Also increasing neopterin levels are well correlated with severity of preeclampsia. So, plasma Neopterin can be used as a clinical biomarker in predicting the severity of preeclampsia in future. Keywords: Neopterin, Preeclampsia, Pregnancy
Publication date: 01/10/2021

https://ijbpas.com/pdf/2021/October/MS_IJBPAS_2021_5638.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.10.5638