ABSTRACT

This review highlights the relation between SARS-CoV, MERS-CoV and n-CoV-19. A review has been done in order to understand and analyse the association between the 3 diseases by retrieving a minimum of 20 articles within the timeframe of 2000 to 2020 from various data search engines including pubmed, Google scholar, MESH, core, bioRXiv, Semantic scholar and so on. All the data were retrieved from the literature studies done by esteemed authors. All the 3 disases, SARS-CoV, MERS-CoV and n-CoV-19 are zoonotic diseases. Research’s have been performed to locate the similarities between SARS CoV, MERS CoV and n- CoV. They are part of the family Coronaviridae and are enveloped viruses with RNA genome. They are mainly related with respiratory diseases and can be highly fatal if left untreated. Disorders of the coagulation pathway and formation of intra alveolar or systemic fibrin clots were also seen in all 3 of the coronavirus infections. Previous studies indicate that MERS CoV affected the type II pneumocytes whereas SARS and SARS 2 affected type I pneumocytes. Comparative studies on MERS CoV, SARS CoV and n-CoV may provide information for treating the present outbreak and to prevent future outbreaks. Due to their close structural and genetic correlation, each viral agent has to be analyzed and studied completely in order to find a prophylaxis and cure. This review highlights on the same and gives an overview on the strain variations and relation within the clades of the corona viruses. Keywords: n-CoV-19; SARS-CoV; MERS-CoV; Prophylaxis; Receptors; Structure
Publication date: 01/08/2021

https://ijbpas.com/pdf/2021/August/MS_IJBPAS_2021_AUG_SPCL_1022.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.8.1022