DNA SEQUENCING AND ITS BENEFITS - A REVIEW Authors: M.Vignesh , M.P.BRUNDHA* AND ARCHANA SANTHANAM
ABSTRACT
The speed, accuracy, efficiency, and cost-effectiveness of DNA sequencing have been improving
continuously since the initial derivation of the technique in the mid-1970s.With the advent of
massively parallel sequencing technologies, DNA sequencing costs have been dramatically
reduced. No longer is it unimaginable to sequence hundreds or even thousands of genes in a
single individual with a suspected genetic disease or complex disease predisposition. Along with
the benefits offered by these technologies comea number of challenges that must be addressed
before wide-scale sequencing becomes accepted medical
practice. Molecular diagnosticians will need to become comfortable with, and gain confidence
in, these new platforms, which are based on radically different technologies compared to the
standard DNA sequencers in routine use today, but despite these obstacles, and as a direct result
of the promises these sequencing advances present, it will likely not be long before nextgeneration
sequencing begins to make an impact in molecular medicine. The aim and importance of this review is to provide DNA sequencing and its benefits and its recent advances to prevent
and diagnose the defective gene and correct it.
Keywords: DNA Sequencing; Sanger; Molecular analysis; nucleotide base pairs Publication date: 01/08/2021 https://ijbpas.com/pdf/2021/August/MS_IJBPAS_2021_AUG_SPCL_1017.pdfDownload PDFhttps://doi.org/10.31032/IJBPAS/2021/10.8.1017
