ABSTRACT

Brain organoids which is also known Cerebral organoids is a self assembled threedimensional structure which is composed of millions of cells that resembles the cellular organization, transcriptional and epigenetic signature of a developing human brain. Key features of early human brains development at molecular, cellular, structural and functional levels are mimicked by brain organoids but the formation of distinct cortical neuronal layers, gyrification and the establishment of complex neuronal circuitry are not fully recapitulated. The main aim in this study was that various features of brain organoids, their application and development are analyzed and recent advances in generation of human brain organoids are discussed and reviewed. This Review was done based on the articles obtained from Various platforms like PubMed, PubMed central and Google scholar. They were collected with a restriction in time basis from 2000 - 2020. The inclusion criteria were original research papers, review articles. In vitro studied among various conditions and articles that contain pros and cons. Exclusion criteria came into account for retracted articles and articles of other languages. All the articles were selected based on Brain organoids. Brain organoids help neuroscientists understand brain development and use of chemical signals to direct stem cells to produce brain-like cells. Stress can be reversed and also access human brain development and disease. Since brain organoids have potential to develop into innovative platforms for pharmacological studies and tissue engineering, more research needs to be done on this in depth for better understanding. Keywords: Brain organoids, cerebral organoids, three-dimensional structure, brain development and disease, stem cells
Publication date: 01/08/2021

https://ijbpas.com/pdf/2021/August/MS_IJBPAS_2021_AUG_SPCL_1006.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.8.1006