ABSTRACT

Pyrazine derivatives are well-known and an important two-nitrogen-containing six-membered ring aromatic heterocyclic compounds. The substituents can be attached to one or more of the carbon atoms present in the ring. Pyrazines are a class of compounds that occur in nature. Pyrazine is a kind of natural product which can be found in plants, animals, insects, marine organisms and microorganisms. The main function of pyrazine in living organisms is used as flavor of the raw foods. Pyrazine and its derivatives were also produced in industries mainly for fragrance, flavor and pharmaceutical applications. A few methods of synthesis of pyrazines are shown in this review. The pyrazines derivatives have numerous prominent pharmacological effects, such as antibacterial, antifungal, antimycobacterial, anti-inflammatory, analgesic, anticancer for different types, antidiabetic, treatment for arteriosclerosis, antiviral. Keywords: Pyrazine, anticancer, antitubercular agents, antibacterial and antifungal
Publication date: 01/09/2021

https://ijbpas.com/pdf/2021/September/MS_IJBPAS_2021_5628.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.9.5628