ABSTRACT

A new schiff base ligand derived based on the condensation of orthophenylenediamine and cinnamaldehyde and coordination complex with Cd(II) have been synthesized. The resulting complex has been characterized by the elemental analysis, melting point, IR and Far-IR spectra, reflectance spectra and NMR (1H & 13C) spectra. The purity of the ligand and its metal complex confirmed by microanalysis and melting point studies. The monomeric and neutral nature of the complex was confirmed by the low conductance value. The electronic spectra of the schiff base and its complex support chromophoric group present in the schiff base and tetrahedral geometry of complex. The IR spectra show the involvement of azomethine nitrogen in coordination to the central metal ion and metal chelates were also confirmed by Far-IR spectra. The NMR spectra of schiff base and its diamagnetic Cd(II) complex shows the magnetic property and geometry of them. The schiff base and its complex were screened for in-vitro antibacterial activity against some gram positive and gram negative bacteria and fungus, the complex is active for some strain of microorganisms and resistant for bacterial and fungal strains. The biological activity and medicinal chemistry properties was further confirmed by pharmacokinetics study. Keywords: Cinnamaldehyde, Schiff base, Cd(II)complex, Antibacterial, Antifungal, Pharmaceutical
Publication date: 01/09/2021

https://ijbpas.com/pdf/2021/September/MS_IJBPAS_2021_5620.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.9.5620