ABSTRACT

Background: Adipokines (adiponectin and leptin), as biomarkers can help to identify the onset of obesity. We observed a direct association between leptin and obesity and an inverse relation between adiponectin and obesity in school going children. With no defined cut-offs in Indian children for leptin and adiponectin to identify obesity, we aimed to find cut-off values of serum adiponectin, leptin concentrations. Methods: A cross sectional study involved a total of 200 school going children in age group of 10 – 20 years. Biochemical parameters, adiponectin and leptin were measured. Results: Optimal cut-off for identification of obesity (based on ROC curve analysis) of adiponectin was 2.5 ?g/mL Optimal cut-off value in females was 0.41 ?g/mL. The analysis demonstrated similar AUC at leptin concentration of 9.76 ng/mL and 17.76 ng/mL with BMI as variable. Optimal cut-off for identification of obesity of leptin was 9.76 ng/mL, resulting in highest sensitivity of 63.4 and specificity of 89.1 in males. In females, optimal cut-off value of 17.76 ng/mL resulted in highest sensitivity of 70.0 and specificity of 73.4. Conclusion: Adipokines could be useful biomarkers for insulin resistance in clinical practice. In obese children, lower values of adiponectin and higher values of leptin were responsible for obesity. The combination of adiponectin and leptin improves diagnostic accuracy at thesecut-offs. We suggest for children, cut-off for plasma adiponectin and leptin 2.5 ?g/mL and 0.41 ?g/mL and 9.76 ng/mL and 17.76 ng/mL in males and females respectively. Keywords: Insulin resistance, Adiponectin, Leptin, Obesity, Adipokines
Publication date: 01/09/2021

https://ijbpas.com/pdf/2021/September/MS_IJBPAS_2021_5613.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.9.5613