ABSTRACT

A simple and accurate RP-HPLC method has been developed for the estimation of Rosiglitazone Maleate (RGZ) in tablet pharmaceutical dosage form using 100; C18 (250 x 4 mm, 5?m) column with mobile phase comprising of acetonitrile: 0.01M ammonium acetate in the ratio 50:50 v/v. The flow rate was 1.0 ml/min and detection was carried out by UV-PDA detector at 245nm. The retention time for RGZ was found to be 3.008min. The linearity range, correlation co-efficient and accuracy of RGZ was found to be 01-200 ?g/ml, 0.9992 and 99.75 – 105.3% respectively. The developed method was found to be simple, precise and accurate for the estimation of RGZ in tablet formulations. Keywords: Rosiglitazone Maleate, RP-HPLC, tablet pharmaceutical dosage form, method development, validation
Publication date: 01/09/2021

https://ijbpas.com/pdf/2021/September/MS_IJBPAS_2021_5604.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.9.5604