ABSTRACT

Background/Aim: The purpose of the study was to prolong the gastric residence time of vildagliptin by designing its gastro-retentive floating Bioadhesive beads. Materials and Methods: Vildagliptin bio-adhesive and/or floating beads were prepared by using magnetic stirrer successfully. Preliminary trial batches were formulated successfully with varying quantity of sodium alginate, 3 preliminary batches were formulated and further evaluated. All the three preliminary batches characterized for important parameters including external Appearance and Size Uniformity Studies, Swelling Index Studies, Entrapment Efficiency Studies, In Vitro Vildagliptin Release Studies, Scanning Electron Microscopy Studies: etc. Results: On the basis of preliminary batches, the F1 batch giving more drug release. So that the F1 batch is used for DoE process. Formulation F5 was selected as an optimum formulation. Results showed that F5 batch of vildagliptin beads containing maximum amount (gave 97.89 ? 1.35) of both variables released for the period of 10 hrs and was falling in the yellow region of overlay plot. Percentage Entrapment Efficiency was found to be in the range of 71.71± 1.20, Estimation of Vildagliptin was found to be in range of 93.03% to 99.12% , buoyancy time was 22 ? 1.45 hours etc. Hence, vildagliptin was considered as optimized gastro-retentive bioadhesive Beads. Conclusion: It can be concluded from this study that the prepared Gastro-retentive beads could reduce the dosage frequency, dose related side effects, and improve the bioavailability. Key words: Vildagliptin, Floating Beads, Design Expert, Gastro-Retentive Drug Delivery System, Sodium Alginate
Publication date: 01/08/21

https://ijbpas.com/pdf/2021/August/MS_IJBPAS_2021_5590.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2021/10.8.5590