ABSTRACT

The identification of Extra Pyramidal Side effects (EPS) like akathisia, rigidity, tremors and dystonic reactions in patients on antipsychotics is essential to determine the impact of extrapyramidal side effects on compliance. The present study included 277 patients attending a private psychiatric clinic and counselling centre. Prior to study initiation, approval was obtained from institutional ethical committee. All the necessary details were obtained from clinical records and by interacting with patients using data collection form. Patients were divided based on the use of atypical antipsychotics and combination of both typical and atypical antipsychotics. Details about drug characteristics like number of antipsychotics prescribed, use of anticholinergics, were recorded. The history and present occurrence of EPS was recorded from patient case sheets and using Simpson Angus Scale. 209 (75.5 %) patients were prescribed with atypical antipsychotics and 68 (24.5 %) patients were prescribed with combination of atypical and typical antipsychotics. Of 209 patients on atypical antipsychotics, 62 patients were on atypical mono therapy among which risperidone was most prescribed 15 (24 %) and least prescribed was clozapine 5 (8 %) and levosulpride 1 (2 %). We observed akathisia in 77 (65 %) patients, rigidity 36 (30 %), tremors in 43 (36 %) and dystonic reactions in 27 (23 %) patients. Side effects were found to be less in patients taking atypical dual therapy compared to patients on atypical monotherapy. In our study, prevalence of antipsychotic use was mostly observed in rural patients. Side effects such as akathisia, tremor, rigidity and dystonic reactions were more prevalent in patients on combination of typical and atypical antipsychotics. Keywords: Typical antipsychotics, atypical antipsychotics, Extrapyramidal Side effects, combination therapy
Publication date: 01/08/21

https://ijbpas.com/pdf/2021/August/MS_IJBPAS_2021_5585.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.8.5585