Peptic ulcer is an open sore within the lining of the stomach, duodenum (beginning of the
small intestine) or oesophagus. Some medications like non-steroidal anti-inflammatory drugs
(NSAIDS) and other drugs induce breakage of mucosa of stomach or duodenum leading to
ulcers. A normal stomach maintains a balance between its aggressive and defensive factor
,pathogenesis of ulcer disease includes an imbalance between gastric offensive factors like
acid, pepsin secretion, Helicobacter pylori (H.pylori), bile salts, ethanol, lipid peroxidation,
nitric oxide (NO) and defensive factors like prostaglandins (PG’S), gastric mucus, blood
flow, mucosal cell shedding, cellular renovation, glycoproteins, mucin secretion, and
antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT)and glutathione levels.
There are various modern management methods of ulcer and it includes inhibition of gastric
acid secretion, to promote gastro protection, to block apoptosis and stimulate epithelial cellproliferation
for effective healing. Animal models area customed to induce ulcer and assess
the anti-ulcer activity of existing drugs as well as newer ones too, Herbal drugs have preserved their importance because of their relatively less toxicity, better acceptability,
compatibility with human body, lesser adverse effects, cost effective, effective and easy
availability. Herbs have also proven helpful with treating gastric ulcers in dose dependent
manner and may be taken fresh or as dried extracts or tinctures. Preliminary phytochemical
screening of those identified the presence of important secondary metabolites like flavonoids
and tannins. A spread of nutritional strategies and dietary supplements have a positive impact
on reducing the symptoms and retarding the event of gastric ulcers.
In this review attempts are made to summarize anti-peptic activity of assorted medicinal
plants which are utilized by rural people, its screening model methods and parameters to be
assessed are reported.
Keywords: Peptic ulcer, antiulcer models, shay rat model, NSAIDS, H. Pylori
Publication date: 01/08/21
https://ijbpas.com/pdf/2021/August/MS_IJBPAS_2021_5576.pdf
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https://doi.org/10.31032/IJBPAS/2021/10.8.5576
