ABSTRACT

The oral route is considered to be the most advantageous, inexpensive and safe method of delivery of drugs due to the highest component of compliance, especially paediatric and geriatric. The final goal of every drug delivery system is the successful delivery of the drug to the body. Orally disintegrating dosage form is the widely preferred commercial product among the various dosage forms: The oral disintegrating films (ODF) of Moxonidine Chloride (MXD)was prepared using HPMC E3, HPMC E6 and Xanthan gum. Using methanol and dichloromethane in a 1:1 ratio, the polymer solution was prepared and held aside for around 5 to 6 hours for polymer swelling. MXD was dissolved in measured quantity of solvents and this drug solution was added to the above polymeric solution. This step was followed by the addition of plasticizers such as PEG 400, Sweetener and flavour was also added. Constancy of drug content is reached by mixing in cyclo blender for 15-20 minutes. The solution was cast on a prepared mould and air dried for 45 minutes. The film was attentive removed from the mould. Keywords: Moxonidine chloride, Orally Disintegrating Film, Drug efficiency
Publication date: 01/08/21

https://ijbpas.com/pdf/2021/August/MS_IJBPAS_2021_5575.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.8.5575