ABSTRACT

Along with prescribed drugs, diabetic patients are using different phytochemicals/herbs having antidiabetic properties. In these cases there is chance of alterations in pharmacokinetics and pharmacodynamics of drug due to interactions. Repaglinide is a meglitinide class of oral antidiabetic drug and it was metabolized by CYP2C8, CYP2C9 and CYP3A4 enzymes. The present study investigates that interaction of repaglinide with allicin. The rats were divided into normal and diabetic groups, studied for different pharmacokinetic parameters like Cmax, AUC0-n, AUCtotal, t½, MRT and the clearance, Vd and pharmacodynamics like body weight, blood glucose level. The result indicates that combination of repaglinide with allicin, improves Cmax, AUC and MRT where as Volume of distribution and clearance decreases. Repaglinide metabolism was decreased with inhibitory action of allicin on CYP3A4. Finally repaglinide in combination with allicin, shows more control on blood glucose levels of diabetic rats. Keywords: Allicin, CYP enzymes, Repaglinide, Pharmacokinetics and pharmacodynamics
Publication date: 01/08/21

https://ijbpas.com/pdf/2021/August/MS_IJBPAS_2021_5533.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.8.5533