ABSTRACT

The Aim of this study was to design and develop Transdermal patches of Telmisartan and Telmisartan plus various extract of Cinnamon bark to find out the bioenhancing effect of various extract of Cinnamon bark. The transdermal patches were formulated using solvent casting technique with the help of various polymers. The Telmisartan drug is used widely for the treatment of hypertension but loses its potential due to less bioavailability. Its bioavailability might be improved by combining bioenhancers like Cinnamon bark. The present study deals with the use of Cinnamon bark extracts for increasing bioavailability of Telmisartan. The absorption of Telmisartan improved by addition of Cinnamon bark extract for formulating the Transdermal patches, this combination may reduce the dose of the drug, patient compliance as well as toxicity of the drug can be reduced to a greater extent. Drug extract and polymer compatibility studied with the help of Fourier Transform infrared Spectroscopy (FTIR).The diffusion examines were performed by utilizing the Franz Diffusion cell and Everted gut Sac method. The best formulation F37 showed thickness 0.322±0.134mm, Weight uniformity 0.129±0.245gm, % Moisture uptake 9.121±2.454 Moisture content 8.116±0.212, % Drug content 80.65±0.678, Folding endurance 32±2.34. Formulation F537 exhibits the highest % cumulative drug release 64.13±1.11% in 8hrs and highest %Drug absorbed 2.994±0.28 in 120 min. Formulation no. F37 shows maximum bioenhancing action compared to all other patches which contains Telmisartan along with the Ethanolic extract of the Cinnamon bark. Keywords: Cinnamon bark, Telmisartan, Cinnamon bark, FTIR, Bioavailability
Publication date: 01/07/21

https://ijbpas.com/pdf/2021/July/MS_IJBPAS_2021_5586.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.7.5586