The solid dispersion system is improved the dissolution properties of poorly soluble drugs. Poor
aqueous solubility leads to physical composition evolution failures. Due to poor aqueous solubility of
drugs in aqueous and low dissolution profiles in water gastrointestinal track fluid frequently directs to
inadequate bioavailability. In present, a large amount of knowledge has been assembled about solid
dispersion technology. Fusion method, solvent method, fusion solvent method, and supercritical fluid
method, kneading method, melt extrusion method, spray-drying method, and dropping method, melt
agglomeration method, are used to prepared the solid dispersion. Solid dispersion techniques have
received significant interest of improving the dissolution rate of highly lipophilic drugs thereby
improving their bioavailability by reducing drug particle size, improving wettability and forming
amorphous particles. The term solid dispersion is dealing with a group of solid products which is
consisting of at least two different components, generally a hydrophilic inert carrier or matrix and a
hydrophobic drug. Classifications of biopharmaceutical system (BCS) class II drugs include those
drugs which have low solubility and high permeability. In this class Solid dispersion is used for
enhancing the bioavailability and oral absorption. In oral administration; some new chemical entities
are not well-absorbed. There are various methods used to control the problems related to
bioavailability issues and oral intake problems are lower bioavailability, high intra and inter-subject
variability, dose proportionality, micro-capsulation, pro-drug formation, complexation, use of
surfactants, salt formation, lipids, cyclodextrins, permeation enhancers, micronization, nano-particles,
solid dispersions, and self-emulsifying etc. In this review article discusses the solid dispersion
technology, limitations, classification and various preparation techniques with its advantages and
disadvantages.
Keywords: Solid dispersion; Solubility; Bioavailability; Biopharmaceutical classification system;
Dissolution
Publication date: 01/07/21
https://ijbpas.com/pdf/2021/July/MS_IJBPAS_2021_5570.pdf
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https://doi.org/10.31032/IJBPAS/2021/10.7.5570
