ABSTRACT

Drug interactions occur when two or more drugs prescribed together drug action are modified by the diet, environmental factors, disease, drug excipients and results in shows harmful effects. Drug interactions can exhibit pharmacokinetic and pharmacodynamic responses increases or reduce the action of the original drug. Pharmacokinetic drug interactions are influenced by alterations in drug absorption, distribution, metabolism or excretion process this can decrease or increase the activity of the interacting drug. Pharmacodynamic interactions occurred with when drug interact with receptor and shows agonist or antagonist responses. The drug interactions responses may be major, moderate, minor can alter the individual drug actions. The severity of drug interactions may create death, disability, life threatening conditions to the patients. Drug interactions can be managed through avoiding the drug combinations, dosage adjustment, educating the heath care professionals and patients about drug interactions severity and dosage adjustment, drug modification practices can promote effective treatment outcomes. Early identifications of risk factors and implementing the software based advanced screening techniques to identify drug interactions and the establishment of drug information centers in the hospitals can prevent the progression of drug harmful effects to the patients. Keywords: Pharmacokinetics, Pharmacodynamics, Drug interactions, Drug information centers, Drug combinations
Publication date: 01/07/21

https://ijbpas.com/pdf/2021/July/MS_IJBPAS_2021_5552.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.7.5552