ABSTRACT

The aim of the present work is to study the in vitro diffusion profile, predict pharmacokinetic parameters and drug release mechanism from the Dexibuprofen loaded modified gel by using different mathematical models. Dexibuprofen loaded novel modified gel was formulated by prototype using Chitosan and Sepineo P 600 as polymers. The in vitro diffusion release study was performed by using Franz diffusion cell apparatus and samples withdrawn upto 300 minutes at a periodic interval. The in vitro diffusion release data were collected, correlated and predicted to determine zero order, first order, Higuchi, Korsmeyer Peppas and Hixson- Crowell with different mathematical models. The selected formulated topical gels (FR3, FR10 and FR18) were compared with the marketed product for drug release, release kinetics and mechanism. The criterion for the best fit model was based on the highest degree of correlation coefficient of drug release profile of Dexibuprofen loaded novel modified gel. All the three formulated gels shown an excellent release, but the FR18 has released 98.78% of drug at the end 300 minutes when compared with other formulations and marketed product. All the topical gels followed zero order release kinetics. All the three formulated, FR3, FR10 and FR18, topical gels showed better pharmacokinetic parameters when compared with the marketed product. From the findings, it is concluded that the drug release pattern of Dexibuprofen FR 18 loaded modified gel obeyed Korsmeyer Peppas power law which is Super case II transport type of drug release mechanism. Keywords: Dexibuprofen, Pharmacokinetic parameters, Franz Diffusion Cell, Release Order of Kinetics, Drug Release Mechanisms, Sepineo P 600
Publication date: 01/07/21

https://ijbpas.com/pdf/2021/July/MS_IJBPAS_2021_5549.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.7.5549