ABSTRACT

Camptothecin and doxorubicin are two eminent anticancer agents. Camptothecin and its derivatives are isolated from the plant sources and doxorubicin is a synthetic anticancer drug. Both are known for significant activity against many kind of cancers like breast cancer, cervical cancer and ovarian cancer. Although both of are proved to be very active against many cancers but still contain many side-effects. Camptothecin derivatives and doxorubicin induce the haemolytic anaemia in the patients. The present study was carried out to compare haemolytic effect of both the drugs on normal erythrocytes.Not only the haemolytic effect of these drugs were studied but also the protective effect of well-known antioxidants in presence of these drug was also studied using osmotic fragility assay. We not only evaluated the oxidative stress of selected anticancer agents but also the protective role of ascorbic acid, ? Carotene, quercetin and tocopherol in camptothecin and doxorubicin treated red blood cells. The results showed that the doxorubicin causes more damage to RBCs than camptothecin at same concentration and condition. The results of protective effect of selected antioxidants showed that ascorbic acid and beta carotene were not able to protect the RBCs by oxidative damage but quercetin and tocopherol had moderate and significant protective effect on red blood cells caused by both the drugs. Keywords: Camptothecin, Doxorubicin, Osmotic Fragility, Antioxidants, Toxicity
Publication date: 01/07/21

https://ijbpas.com/pdf/2021/July/MS_IJBPAS_2021_5547.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2021/10.7.5547