DEHYDRO-?-LAPACHONE OBTAINED FROM HANDROANTHUS INCANUS SPECIES DISPLAYS AEDES AEGYPTI LARVICIDAL ACTIVITY
Authors: Garcia LFA , SOUSA JPB, MELO SJD, ALBERNAZ LC, ESPINDOLA LS AND CORREIA MV*

ABSTRACT
Handroanthus incanus wood from certified logging concession, afforded two active compounds against Aedes aegypti larvae: lapachol (1) and dehydro-?-lapachone (2). The larvicidal action of lapachol observed in this work is compatible with published data. This is the first publication of a dehydro-?-lapachone larvicidal assay revealing it as a potential natural larvicidal agent, since this compound is considered non-toxic and exhibits high activity (LC50 43.38 ppm) according to the criteria commonly used in the literature. Larvicidal assays of Peltogyne lecointei, Martiodendron elatum, Dipteryx odorata, Erisma uncinatum and Allantoma decandra crude extracts showed no larvicidal activity. Keywords: Handroanthus incanus; Aedes aegypti; lapachol; dehydro-?-lapachone
Publication date: 01/07/21
    https://ijbpas.com/pdf/2021/July/MS_IJBPAS_2021_5521.pdf
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https://doi.org/10.31032/IJBPAS/2021/10.7.5521