ABSTRACT

The present study was aimed to formulate, develop and evaluate the immediate release tablet of synthetic glucocorticoid using various disintegrants and to observe the dissolution profile of drug product. The different disintegrant used like a partially gelatinized starch, sodium starch glycolate, crosscarmellose sodium in various concentration to achieve the drug release profile compare to RLD product. The super disintegrants like partially gelatinized starch, sodium starch glycolate, crosscarmellose sodium which shows different mechanism of action to disintegrate the tablet. So, for good dissolution profile as compare with RLD product we use various disintegrants at different concentration. The generic tablet of dexamethasone 6mg was prepared by considering the approved reference product in Europe. The tablet was prepared by direct compression method. The excipient was used is based on the excipient which is used in reference listed product. Regarding a dissolution time we can prepare 6 optimized batches by OFAT drug design changing a concentration of disintegrant also a different disintegrants which shows the different dissolution profile and select the proper composition. Keywords: Dexamethasone, synthetic glucocorticoids, disintegrants, dissolution profile
Publication date: 01/06/21

https://ijbpas.com/pdf/2021/June/MS_IJBPAS_2021_5543.pdf

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https://doi.org/10.31032/IJBPAS/2021/10.6.5543